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  • Synthesis of functionalized chromans by PnBu3-catalyzed reactions of salicylaldimines and salicylaldehydes with allenic ester.

Synthesis of functionalized chromans by PnBu3-catalyzed reactions of salicylaldimines and salicylaldehydes with allenic ester.

Organic letters (2010-11-13)
Yin-Wei Sun, Xiao-Yang Guan, Min Shi
ABSTRACT

P(n)Bu(3)-catalyzed cyclization reactions of salicylaldimines and salicylaldehydes with ethyl 2,3-butadienoate gave the corresponding functionalized chromans in moderate to good yields in THF under mild conditions. The new reaction provides a new method for the synthesis of biologically active chroman products.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Tri-n-butylphosphine, 99%
Sigma-Aldrich
Tributylphosphine solution, 200 mM (in N-methyl-2-pyrrolidinone), liquid
Sigma-Aldrich
Tri-n-butylphosphine, 97%
Sigma-Aldrich
Tributylphosphine, ≥93.5% (Tri-N-butylphosphine, GC)
Sigma-Aldrich
Tributylphosphine, mixture of isomers, 97%