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  • Tandem Blaise-alkenylation with unactivated alkynes: one-pot synthesis of alpha-vinylated beta-enaminoesters from nitriles.

Tandem Blaise-alkenylation with unactivated alkynes: one-pot synthesis of alpha-vinylated beta-enaminoesters from nitriles.

Organic letters (2009-07-04)
Yu Sung Chun, Young Ok Ko, Hyunik Shin, Sang-gi Lee
ABSTRACT

The in situ generated Blaise reaction intermediate, a zinc bromide complex of beta-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford alpha-vinylated beta-enaminoesters in good to excellent yields.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Zinc bromide, 99.999% trace metals basis
Sigma-Aldrich
Zinc bromide, AnhydroBeads, −10 mesh, 99.999% trace metals basis