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A4626

Sigma-Aldrich

1-Acetyl-2-phenylhydrazine

≥98%

Synonym(s):

N-Acetyl-N′-phenylhydrazine, acetylphenylhydrazine

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About This Item

Linear Formula:
CH3CONHNHC6H5
CAS Number:
114-83-0
Molecular Weight:
150.18
EC Number:
204-055-3
MDL number:
MFCD00008672
UNSPSC Code:
12352127
PubChem Substance ID:
24890888
NACRES:
NA.25

Assay

≥98%

form

(Powder with Chunk(s) or Crystals with Chunk(s))

mp

128-131 °C (lit.)

SMILES string

CC(=O)NNc1ccccc1

InChI

1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)

InChI key

UICBCXONCUFSOI-UHFFFAOYSA-N

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Application

1-Acetyl-2-phenylhydrazine (AcPhHZ) which reacts with oxyhaemoglobin to form free radicals may be used to induce haemolytic anaemia for studies of the hematopoietic system.

Biochem/physiol Actions

1-Acetyl-2-phenylhydrazine (AcPhHZ) is a vascular tumor initiator used in experimental animal model.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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2-Phenylacetohydrazide for synthesis

Sigma-Aldrich

8.20561

2-Phenylacetohydrazide

Simonetta Croci et al.
Anticancer research, 22(5), 2903-2906 (2003-01-18)
The end result of our research would be the development of a new diagnostic technique that could be used as a screening test, starting from a simple blood collection, a common procedure without any risk to the subject. Red blood
G Bartosz et al.
Clinica chimica acta; international journal of clinical chemistry, 198(3), 239-243 (1991-05-15)
Erythrocytes of Down syndrome patients, having increased activity of superoxide dismutase and glutathione peroxidase, showed a similar increase in intracellular proteolysis upon stimulation with 1 mmol/l phenylhydrazine than normal erythrocytes. There were no differences in the magnitude of Heinz body
High activity antioxidant enzymes protect flying-fox haemoglobin against damage: an evolutionary adaptation for flight?
Reinke NB, O'Brien GM.
Journal of Comparative Pathology, 176, 729-737 (2006)
Y Manabe et al.
The Journal of toxicological sciences, 25(3), 161-165 (2000-09-15)
In this study, a new simple method to measure erythrocyte fragility with stirring of diluted blood (stirring method) was introduced and evaluated with anemic rats given beta-acetylphenylhydrazine (APHZ) or clofibrate. APHZ at a dose of 40 mg/kg caused significant decreases
H Ohno et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 32(2), 269-277 (1996-08-01)
A previous study revealed that DQ-2511, a new gastroprokinetic drug, induced hemolytic anemia together with increased Heinz body formation, preceded by a marked decrease in erythrocyte reduced glutathione (GSH) content, after 2 weeks of dosing onward in dogs. In this
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