44583

Doxorubicin hydrochloride

suitable for fluorescence, 98.0-102.0% (HPLC)

• Synonym(s): DOX, Hydroxydaunorubicin hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₁ · HCl
• CAS Number: 25316-40-9
• Molecular Weight: 579.98
• Beilstein: 4229251
• EC Number: 246-818-3
• MDL number: MFCD00077757
• UNSPSC Code: 51281818
• PubChem Substance ID: 57650234
• NACRES: NA.76

Properties

• biological source: synthetic
• Assay: 98.0-102.0% (HPLC)
• form: solid
• color: orange to dark red
• mp: 216 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL, clear, orange to red; DMSO: soluble; THF: soluble; ethanol: soluble; methanol: soluble
• fluorescence: λ_em 580-590 nm
• suitability: suitable for fluorescence
• antibiotic activity spectrum: neoplastics
• Mode of action: DNA synthesis | interferes; enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-RUELKSSGSA-N
• Gene Information: human ... TOP2A(7153)

Description

General description

Chemical structure: tetracycline

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Biochem/physiol Actions

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H340,H350,H360FD
• Precautionary Statements: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves