901767

PC biotin-PEG3-NHS ester

• Synonym(s): PC biotin-NHS ester
• Empirical Formula (Hill Notation): C₃₆H₅₂N₆O₁₅S
• CAS Number: 2353409-93-3
• Molecular Weight: 840.89
• UNSPSC Code: 51171641
• NACRES: NA.22

Properties

• form: solid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent
• mp: 170 °C
• storage temp.: −20°C

Description

Application

PC biotin-NHS ester is a unique amine-reactive, photocleavable biotin reagent that allows for reagent-free release of the captured biomolecules from streptavidin. This reagent contains a biotin moiety linked to the amine reactive N-hydroxysuccinimidyl (NHS) mixed carbonate through a spacer arm containing a photocleavable moiety. The NHS portion of this compound reacts specifically with primary amine groups on the target molecule(s) to form a carbamate linkage. Captured biomolecules can be efficiently photoreleased, typically >90% in 5-25 minutes using an inexpensive, near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm²).

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable