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345996

Sigma-Aldrich

Glial Fibrillary Acidic Protein, Human Brain

Synonym(s):

GFAP

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About This Item

UNSPSC Code:
12352202

Assay

≥90% (SDS-PAGE)

Quality Level

100

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

distilled water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Native, glial fibrillary acidic protein purified from human brain. Main component of the intermediate filaments in astrocytes. Marker of sclerotic plaques in gliosed brain.
Native, glial fibrillary acidic protein purified from human brain. Marker of sclerotic plaques in brain and gliosed brain. Isolated from normal human brain. A component of astroglial intermediate filaments. Forms glial filaments in astrocytes in the central nervous system and in some Schwann cells in peripheral nerves.



Molecular Weight: 43,000-49,000

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 16 mM Sodium Bicarbonate, pH 8.5.

Preparation Note

Prepared from tissues of individuals that have been shown by certified tests to be negative for HbsAg, HIV-1 and HIV-2 antibodies, HCV, and syphilis.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Anderiva, M., et al. 2001. Glia35, 189.
Masood, K., et al. 1993. J. Neurochem. 61, 160.
Liem, R.K., and Hutchison, S.B. 1982. Biochemistry21, 3221.
Dahl, D. 1973. Brain Res.57, 343.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Astrocytes become activated with certain infections, and this might alter the brain to trigger or worsen depressed mood. Indeed, astrocytes are chronically activated in people with HIV infection (PWH), who are much more frequently depressed than people without HIV (PWoH).
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Lamotrigine trial in SPMS was a randomised control trial to assess whether partial blockade of sodium channels has a neuroprotective effect. The current study was an additional study to investigate the value of neurofilament (NfH) and other biomarkers in predicting

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