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  • SOD1 plasma level as a biomarker for therapeutic failure in cutaneous leishmaniasis.

SOD1 plasma level as a biomarker for therapeutic failure in cutaneous leishmaniasis.

The Journal of infectious diseases (2014-02-11)
Ricardo Khouri, Gilvaneia Silva Santos, George Soares, Jackson M Costa, Aldina Barral, Manoel Barral-Netto, Johan Van Weyenbergh
ABSTRACT

We show that increased plasma superoxide dismutase 1 (SOD1) levels are statistically significant predictors of the failure of pentavalent antimony treatment for cutaneous leishmaniasis caused by Leishmania braziliensis. In Leishmania amazonensis-infected patients, host SOD1 levels can be used to discriminate between localized and drug-resistant diffuse cutaneous leishmaniasis. Using in situ transcriptomics (nCounter), we demonstrate a significant positive correlation between host SOD1 and interferon α/β messenger RNA (mRNA) levels, as well as interkingdom correlation between host SOD1 and parasite SOD2/4 mRNA levels. In human macrophages, in vitro treatment with SOD1 increases the parasite burden and induces a diffuse cutaneous leishmaniasis-like morphology. Thus, SOD1 is a clinically relevant biomarker and a therapeutic target in both localized and diffuse cutaneous leishmaniasis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Antimony, beads, ≤5 mm, low oxide, 99.999% trace metals basis
Sigma-Aldrich
Antimony, powder, -100 mesh, 99.5% trace metals basis
Antimony, foil, not light tested, 25x25mm, thickness 0.015mm, permanent polyester support, 95+%
Antimony, microfoil, 50x50mm, thinness 0.5μm, specific density 334.5μg/cm2, 6 micron aluminum permanent support, 95+%
Antimony, rod, 20mm, diameter 4.7mm, 99.999%
Antimony, foil, not light tested, 100x100mm, thickness 0.015mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 100x100mm, thickness 0.05mm, permanent polyester support, 95+%
Antimony, microfoil, 25x25mm, thinness 0.5μm, specific density 334.5μg/cm2, 6 micron aluminum permanent support, 95+%
Antimony, foil, not light tested, 50x50mm, thickness 0.05mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 25x25mm, thickness 0.005mm, permanent polyester support, 95+%
Antimony, rod, 15mm, diameter 2.0mm, 99.99%
Antimony, foil, 50x50mm, thickness 2mm, hot-pressed
Antimony, foil, light tested, 50x50mm, thickness 0.05mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 50x50mm, thickness 0.005mm, permanent polyester support, 95+%
Antimony, rod, 50mm, diameter 4.7mm, 99.999%
Antimony, foil, not light tested, 100x100mm, thickness 0.01mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 100x100mm, thickness 0.025mm, permanent polyester support, 95+%
Antimony, rod, 6mm, diameter 6mm, 99.999%
Antimony, rod, 25mm, diameter 2.0mm, 99.99%
Antimony, foil, light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 50x50mm, thickness 0.002mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 50x50mm, thickness 0.025mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 25x25mm, thickness 0.002mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 95+%
Antimony, rod, 50mm, diameter 2.0mm, 99.99%
Antimony, foil, not light tested, 50x50mm, thickness 0.015mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 95+%
Antimony, foil, not light tested, 50x50mm, thickness 0.01mm, permanent polyester support, 95+%