Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS

Product Number

Brand

Product Description

349380

Sigma-Aldrich

Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

298093

Sigma-Aldrich

Platinum, gauze, 100 mesh, 99.9% trace metals basis

357375

Sigma-Aldrich

Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis

205915

Sigma-Aldrich

Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

327484

Sigma-Aldrich

Platinum, shot, ≤3 mm, ≥99.9% trace metals basis

267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

444685

Sigma-Aldrich

Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

GF90209684

Platinum, wire reel, 0.5m, diameter 0.0006mm, wollaston, 99.9%

GF56233919

Platinum, wire reel, 0.2m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%

GF39961862

Platinum, wire reel, 1m, diameter 0.25mm, hard, 99.95%

GF33148661

Platinum, wire reel, 20m, diameter 0.08mm, hard, 99.9%

GF31782708

Platinum, wire reel, 1m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%

GF86119038

Platinum, wire reel, 0.2m, diameter 1.0mm, as drawn, 99.99+%

GF93729134

Platinum, wire reel, 5m, diameter 0.02mm, as drawn, 99.9%

GF74891302

Platinum, wire reel, 2m, diameter 0.08mm, hard, 99.9%

GF29339286

Platinum, wire reel, 1m, diameter 0.01mm, hard, 99.9%

GF14989641

Platinum, foil, 8mm disks, thickness 0.0125mm, as rolled, 99.95%

GF62037772

Platinum, wire reel, 1m, diameter 0.0125mm, hard, 99.9%

GF03899931

Platinum, wire reel, 2m, diameter 0.3mm, annealed, may be used as one component of a thermocouple, 99.99%

GF36080861

Platinum, wire reel, 0.2m, diameter 0.175mm, as drawn, 99.95%

GF02102948

Platinum, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.99+%

GF85102837

Platinum, wire reel, 0.1m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%

GF15145286

Platinum, wire reel, 1m, diameter 0.025mm, annealed, may be used as one component of a thermocouple, 99.99%

GF14090644

Platinum, wire reel, 1m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%