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M84607

Sigma-Aldrich

N-Methylthiourea

97%

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About This Item

Linear Formula:
NH2CSNHCH3
CAS Number:
598-52-7
Molecular Weight:
90.15
Beilstein:
506162
EC Number:
209-936-6
MDL number:
MFCD00004938
UNSPSC Code:
12352100
PubChem Substance ID:
24897263
NACRES:
NA.22

Assay

97%

form

crystals

mp

118-121 °C (lit.)

SMILES string

CNC(N)=S

InChI

1S/C2H6N2S/c1-4-2(3)5/h1H3,(H3,3,4,5)

InChI key

KQJQICVXLJTWQD-UHFFFAOYSA-N

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Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H300,H411

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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T S Plantinga et al.
Clinical pharmacology and therapeutics, 102(6), 1017-1024 (2017-05-10)
Agranulocytosis is a rare and serious adverse effect of antithyroid drugs, with unknown etiology. The present study aimed to uncover genetic susceptibility and underlying mechanisms of antithyroid drug-induced agranulocytosis (ATDAC). We studied two independent families with familial Graves' disease, of
Shruti Sharma et al.
International journal of molecular sciences, 14(1), 255-272 (2013-01-25)
Congenital heart defects with increased pulmonary blood flow (PBF) result in pulmonary endothelial dysfunction that is dependent, at least in part, on decreases in nitric oxide (NO) signaling. Utilizing a lamb model with left-to-right shunting of blood and increased PBF
A R Jones et al.
Xenobiotica; the fate of foreign compounds in biological systems, 13(2), 73-79 (1983-02-01)
1. The fate of N-methyl-N'-(hydroxy[14C]methyl)thiourea (MHT) has been studied in the male Sprague-Dawley rat. The compound is degraded to N-methylthiourea and formaldehyde. 2. N-Methylthiourea is excreted as a urinary metabolite whereas the formaldehyde is not excreted, either in the urine
Structure-toxicity relationships for the effects of N- and N,N'-alkyl thioureas to Tetrahymena pyriformis.
T W Schultz et al.
Bulletin of environmental contamination and toxicology, 70(6), 1251-1258 (2003-05-21)
Reza Heidari et al.
Scientia pharmaceutica, 80(4), 987-999 (2012-12-25)
Methimazole is used as an antithyroid drug to control the symptoms of hyperthyroidism and maintain patients in a euthyroid state. Administration of this drug is associated with agranulocytosis and hepatotoxicity, which are the two most significant adverse effects. The present
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