Custom miRNA

Micro RNAs (miRNAs) orchestrate crucial regulatory functions related to cell growth, development, and differentiation. Human miRNAs are likely to be useful as biomarkers, especially for future cancer diagnostics, and are rapidly emerging as attractive targets for disease intervention.

miRNA research is the backbone of many of the most cutting-edge medical therapies of tomorrow thus, to keep up with the growing interest in miRNA, we have made a strong commitment to this rapidly developing area of research. We synthesize custom miRNA using your sequences or sequences we have bioinformatically designed for you.

Product Benefits

• Complimentary designs that mimic our Predesigned miRNA Mimics designs
• Distinguish sequence-specific silencing from non–specific effects with 2 negative control miRNA
• Custom services allow for flexibility in experimental setup

Product Features

• For anything marked as ‘Inquire’ below or If you have needs that are different from the other general specifications presented, please send a request to sirnarequest@sial.com.

Custom miRNA Specifications
Quantities	2 (10 nmol), 5 (25 nmol), 10 (50 nmol) & 50 (250 nmol) OD For larger quantities & in-vivo-grade material, see our Custom iScale Oligos product
Purification	Desalt or HPLC
Sequence Form	19 to 27mer duplexes
Modifications	Biotin, Phosphate, Amino-Modifier C7, 6-FAM™, Cyanine 3, Cyanine 5, Cyanine 5.5, 2’-OMe, Phosphorothioate, Thiol-Modifier C6 S-S & Thiol-Modifier C3 Inquire for feasibility of Locked Nucleic Acid & other modifications
Quality Control	100% mass spectrometry**
Format	Supplied dry in tubes or plates Pooling & aliquoting available (inquire for feasibility)

**Depending on the manufacturing site, PAGE may be used to assess miRNA duplexes.

If additional help is needed, please consult our technical services group at oligotechserv@sial.com.