TRC Library Citations

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The MISSION^® TRC1.5 human and mouse shRNA libraries are the proven performers for small-scale to high-throughput RNAi screening. Below you will find a selection of papers where researchers have published in peer-reviewed journals using the TRC1/1.5 library and have cited The Broad Institute or Sigma-Aldrich_® as their source of high quality reagents. Unlike other shRNA libraries, the clones cited in these publications are the same clones available from Sigma-Aldrich. If a specific clone is not found in our catalog, please inquire here for availability.

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How to Cite the TRC Library

In scientific publications, the human library should be referred to as MISSION^® TRC-Hs 1.0 (Human) while the mouse library should be referred to as MISSION^® TRC-Mm 1.0 (Mouse). If your TRC library was purchased after July 2011, the human library should be referred to as MISSION^® TRC-Hs 1.5 (Human) while the mouse library should be referred to as MISSION^® TRC-Mm 1.5 (Mouse). If you experimented with our TRC2 library, the human library should be referred to as MISSION^® TRC-Hs 2.0 (Human) while the mouse library should be referred to as MISSION^® TRC-Mm 2.0 (Mouse).Individual clones should be identified by their unique TRC number (e.g. MISSION^® TRC shRNA TRCN0000030720).

MISSION® shRNA Publications

Title	Author / Journal	Abstract
Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma.	Lachke, S.A. et al. Science. 2011. 331: 1571-1576	abstract
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.	Sevlever, D. et al. Biochemistry. 2008. 47: 9678-9687	abstract
EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance.	Zhang, Y, et al. Molecular Cancer Therapeutics. 2008.7:3176.	abstract
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.	Zhang, XY, et al. Mol Cell. 2008.29: 102-11.	abstract
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.	Zeng, X, et al. Development. 2008.135: 367-75.	abstract
Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest.	Yang, WS, et al. Genome Biol. 2008.9: R92.	abstract
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.	Yamashita, M, et al. J Exp Med. 2008.205: 1109-20.	abstract
Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells.	Wimmer-Kleikamp, SH, et al. Blood. 2008.112: 721-32.	abstract
Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells.	Wierzbicki, A, et al. J Immunol. 2008.181: 6644-53.	abstract
Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells.	Wei, D, et al. Cancer Res. 2008.68: 4631-9.	abstract
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1.	Vasilcanu, R, et al. Oncogene. 2008.27: 1629-38.	abstract
Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway.	Varghese, B, et al. Mol Cell Biol. 2008.28: 5275-87.	abstract
Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells.	Ueffing, N, et al. Blood. 2008.112: 690-8.	abstract
Inhibition of" self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells.	Tsai, R, et al. The Journal of Cell Biology. 2008.180:989.	abstract
Phospholipase D1 is an effector of Rheb in the mTOR pathway.	Sun, Y, et al. Proc Natl Acad Sci U S A. 2008.105: 8286-91.	abstract
The beta1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA+-induced motility of gastric cancer cells.	Snider, JL, et al. J Biol Chem. 2008.283: 13952-63.	abstract
Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages.	Sierra, J, et al. Journal of Experimental Medicine. 2008.205:1673.	abstract
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.	Shimamura, T, et al. Cancer Res. 2008.68: 5827-38.	abstract
Differentiation of Neural Stem Cells into Oligodendrocytes: Involvement of the Polycomb Group Protein Ezh2.	Sher, F, et al. Stem Cells. 2008.26:2875.	abstract
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.	Shema, E, et al. Genes & Development. 2008.22:2664.	abstract
Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms.	Shaikh, FM, et al. Exp Cell Res. 2008.314: 2941-50.	abstract
Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis.	Sen, N, et al. Nature Cell Biology. 2008.10:866.	abstract
Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination.	Roukens, MG, et al. Mol Cell Biol. 2008.28: 4394-406.	abstract
A Sensitive Flow Cytometry-based Nucleotide Excision Repair Assay Unexpectedly Reveals That Mitogen-activated Protein Kinase Signaling Does Not Regulate the Removal of UV-induced DNA Damage in Human Cells.	Rouget, R, et al. J Biol Chem. 2008.283: 5533-41.	abstract
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.	Pfister, S, et al. J Clin Invest. 2008.118: 1739-49.	abstract
Identification of Pbx1, a Potential Oncogene, as a Notch3 Target Gene in Ovarian Cancer.	Park, J, et al. Cancer Research. 2008.68:8852.	abstract
TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.	Park, Y, et al. Biochem Biophys Res Commun. 2008.374: 294-8.	abstract
SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death.	Nogueira, E, et al. J Biol Chem. 2008.283: 16248-58.	abstract
Genetic Complementation Screen Identifies a Mitogen-activated Protein Kinase Phosphatase, MKP3, as a Regulator of Dopamine Transporter Trafficking.	Mortensen, O, et al. Molecular Biology of the Cell. 2008.19:2818.	abstract
Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases.	Martin-Granados, C, et al. Int J Biochem Cell Biol. 2008.40: 2315-32.	abstract
Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation.	Magenta, A, et al. Mol Cell Biol. 2008.28: 873-82.	abstract
Human Cytomegalovirus Protein pp71 Displaces the Chromatin Associated Factor ATRX from Nuclear Domain 10 at Early Stages of Infection.	Lukashchuk, V, et al. Journal of Virology. 2008.epublication ahead of print:.	abstract
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.	Loo, YM, et al. J Virol. 2008.82: 335-45.	abstract
HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma.	Liau, SS, et al. Clin Cancer Res. 2008.14: 1470-7.	abstract
SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects.	Lepagnol-Bestel, AM, et al. Mol Psychiatry. 2008.13: 385-97.	abstract
An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.	Lamar, JM, et al. Cancer Res. 2008.68: 7371-9.	abstract
VIP and VIP gene silencing modulation of differentiation marker N-cadherin and cell shape of corneal endothelium in human corneas ex vivo.	Koh, SW, et al. Invest Ophthalmol Vis Sci. 2008.49: 3491-8.	abstract
Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway.	Kim, JH, et al. J Biol Chem. 2008.283: 708-15.	abstract
DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.	Kappes, F, et al. Mol Cell Biol. 2008.28: 3245-57.	abstract
Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells.	Jong, A, et al. Cellular Microbiology. 2008.epublication ahead of print:.	abstract
Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress.	Jiang, C, et al. Cancer Research. 2008.68:6708.	abstract
Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.	Jiang, CC, et al. Cancer Res. 2008.68: 6708-17.	abstract
Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells.	Ji, Z, et al. J Biol Chem. 2008.283: 21920-5.	abstract
Epigenetic silencing of O6-methylguanine-DNA methyltransferase gene in NiS-transformed cells.	Ji, W, et al. Carcinogenesis. 2008.epublication ahead of print:.	abstract
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.	Janoueix-Lerosey, I, et al. Nature. 2008.455: 967-70.	abstract
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.	Ishikawa, H, et al. Nature. 2008.455: 674-8.	abstract
Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway.	Hoskins, E, et al. Oncogene. 2008.epublication ahead of print:.	abstract
Targeting AKT Signaling Sensitizes Cancer to Cellular Immunotherapy.	Hahnel, P, et al. Cancer Research. 2008.68:3899.	abstract
A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion.	Gu, J, et al. FEBS Journal. 2008.275: 3145-56.	abstract
Deferiprone targets aconitase: implication for Friedreich's ataxia treatment.	Goncalves, S, et al. BMC Neurol. 2008.8:20.	abstract
Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau.	Gendron, TF, et al. Neurosci Lett. 2008.443: 67-71.	abstract
Induction of autophagy during extracellular matrix detachment promotes cell survival.	Fung, C, et al. Mol Biol Cell. 2008.19: 797-806.	abstract
Malignant pleural mesothelioma-targeted CREBBP/EP300 inhibitory protein 1 promoter system for gene therapy and virotherapy.	Fukazawa, T, et al. Cancer Res. 2008.68: 7120-9.	abstract
Matrix metalloproteinase-10 is a critical effector of protein kinase C iota-Par6 alpha-mediated lung cancer.	Frederick, L, et al. Oncogene. 2008.epublication ahead of print:.	abstract
Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells.	Fattah, FJ, et al. Proc Natl Acad Sci U S A. 2008.105: 8703-8.	abstract
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis.	Escriva, M, et al. Mol Cell Biol. 2008.28: 1528-40.	abstract
Interferon regulatory factors are transcriptional regulators of adipogenesis.	Eguchi, J, et al. Cell Metab. 2008.7: 86-94.	abstract
Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer.	Duan, Z, et al. Mol Cancer Ther. 2008.7: 2377-85.	abstract
Functional characterization of the atopy-associated gene PHF11.	Clarke, E, et al. J Allergy Clin Immunol. 2008.121: 1148-54 e3.	abstract
Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function.	Cheng, G, et al. Journal of Biological Chemistry. 2008.283:14665.	abstract
Widespread microRNA repression by Myc contributes to tumorigenesis.	Chang, TC, et al. Nat Genet. 2008.40: 43-50.	abstract
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle Stem Cells.	Carlson, ME, et al. Nature. 2008.454: 528-32.	abstract
The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors.	Caramel, J, et al. Oncogene. 2008.27: 2035-44.	abstract
RhoA-dependent regulation of cell migration by the tumor suppressor hSNF5/INI1.	Caramel, J, et al. Cancer Res. 2008.68: 6154-61.	abstract
E1a gene expression blocks the ERK1/2 signaling pathway by promoting nuclear localization and MKP up-regulation: implication in v-H-Ras-induced senescence.	Callejas-Valera, JL, et al. J Biol Chem. 2008.283: 13450-8.	abstract
p63 regulates the caspase-8-FLIP apoptotic pathway in epidermis.	Borrelli, S, et al. Cell Death & Differentiation. 2008.epublication ahead of print:.	abstract
Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.	Bernard-Pierrot, I, et al. Cancer Res. 2008.68: 7165-75.	abstract
Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth.	Bao, S, et al. Cancer Research. 2008.68:6043.	abstract
HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate: mechanism and implications for Tax oncogenicity.	Azran-Shaish, I, et al. J Mol Med. 2008.86: 799-814.	abstract
Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains.	Al-Hakim, AK, et al. Biochem J. 2008.	abstract
Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth.	Ahmed, A, et al. JNCI Journal of the National Cancer Institute. 2008.epublication ahead of print:.	abstract
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.	Yang, L, et al. J Biol Chem. 2007.282: 10981-7.	abstract
Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells.	Villa-Moruzzi, E, Biochem J. 2007.408: 7-18.	abstract
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.	Vander Haar, E, et al. Nat Cell Biol. 2007.9: 316-23.	abstract
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis.	Scholl, C, et al. J Clin Invest. 2007.117: 1037-48.	abstract
Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.	Schmidt, RL, et al. Cancer Res. 2007.67: 11798-810.	abstract
Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.	Sanchez-Sanchez, F, et al. J Biol Chem. 2007.282: 27810-24.	abstract
The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells.	Rizzi, M, et al. J Leukoc Biol. 2007.81: 1599-608.	abstract
c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation.	Ravitz, MJ, et al. Cancer Res. 2007.67: 11209-17.	abstract
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis.	Qian, YW, et al. J Lipid Res. 2007.48: 1488-98.	abstract
Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression.	Pottier, N, et al. Hum Mol Genet. 2007.16: 2261-71.	abstract
BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis.	Patel, JH, et al. J Biol Chem. 2007.282: 5-13.	abstract
Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse Development.	Pallerla, SR, et al. Dev Dyn. 2007.236: 556-63.	abstract
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.	Neilson, LM, et al. Mol Endocrinol. 2007.21: 2218-32.	abstract
HOXB13 promotes ovarian cancer progression.	Miao, J, et al. Proc Natl Acad Sci U S A. 2007.104: 17093-8.	abstract
Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells.	Liau, SS, et al. Br J Cancer. 2007.96: 993-1000.	abstract
TTF-1 regulates growth hormone and prolactin transcription in the anterior pituitary gland.	Lee, NO, et al. Biochem Biophys Res Commun. 2007.362: 193-9.	abstract
Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein.	Lee, H, et al. Mol Cell Biol. 2007.27: 2103-19.	abstract
Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.	Kim, JS, et al. Mol Cell Biol. 2007.27: 662-77.	abstract
GATA-6 mediates human bladder smooth muscle differentiation: involvement of a novel enhancer element in regulating alpha-smooth muscle actin gene expression.	Kanematsu, A, et al. Am J Physiol Cell Physiol. 2007.293: C1093-102.	abstract
A screen of shRNAs targeting tumor suppressor genes to identify factors involved in A549 paclitaxel sensitivity.	Ji, D, et al. Oncol Rep. 2007.18: 1499-505.	abstract
Non-classical export of epimorphin and its adhesion to alphav-integrin in regulation of epithelial morphogenesis.	Hirai, Y, et al. J Cell Sci. 2007.120: 2032-43.	abstract
cFLIPL prevents TRAIL-induced apoptosis of hepatocellular carcinoma cells by inhibiting the lysosomal pathway of apoptosis.	Guicciardi, ME, et al. Am J Physiol Gastrointest Liver Physiol. 2007.292: G1337-46.	abstract
Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?	Grimm, D, et al. J Clin Invest. 2007.117: 3633-41.	abstract
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.	Gatot, JS, et al. J Biol Chem. 2007.282: 31131-46.	abstract
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.	Frohling, S, et al. Cancer Cell. 2007.12: 501-13.	abstract
Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.	Fang, HL, et al. J Pharmacol Exp Ther. 2007.323: 586-98.	abstract
Heat shock factor 1 is a powerful multifaceted modifier of Carcinogenesis.	Dai, C, et al. Cell. 2007.130: 1005-18.	abstract
EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.	Cortina, C, et al. Nat Genet. 2007.39: 1376-83.	abstract
Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer.	Chiappetta, G, et al. Endocr Relat Cancer. 2007.14: 405-20.	abstract
Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage.	Cheng, A, et al. J Neurosci. 2007.27: 3722-33.	abstract
Expression of the voltage-gated sodium channel NaV1.5 in the macrophage late endosome regulates endosomal acidification.	Carrithers, MD, et al. J Immunol. 2007.178: 7822-32.	abstract
Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells.	Bush, CR, et al. J Biol Chem. 2007.282: 23387-401.	abstract
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.	Binne, UK, et al. Nat Cell Biol. 2007.9: 225-32.	abstract
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.	Bar, EE, et al. Stem Cells. 2007.25: 2524-33.	abstract
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.	Yousefi, S, et al. Nat Cell Biol. 2006.8: 1124-32.	abstract
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	Takeda, S, et al. Genes Dev. 2006.20: 2397-409.	abstract
Acetylation of the p53 DNA-binding domain regulates apoptosis induction.	Sykes, SM, et al. Mol Cell. 2006.24: 841-51.	abstract
Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling.	Smoak, K, et al. Mol Cell Biol. 2006.26: 9126-35.	abstract
Genome-scale loss-of-function screening with a lentiviral RNAi library.	Root, DE, et al. Nat Methods. 2006.3: 715-9.	abstract
Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma.	Liau, SS, et al. J Gastrointest Surg. 2006.10: 1254-62; discussion 63.	abstract
HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma.	Liau, SS, et al. Cancer Res. 2006.66: 11613-22.	abstract
Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase.	Fu, Z, et al. Mol Cell Biol. 2006.26: 8639-54.	abstract
PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0.	Everett, RD, et al. J Virol. 2006.80: 7995-8005.	abstract
Axl receptor activation mediates laminar shear stress anti-apoptotic effects in human endothelial cells.	D'Arcangelo, D, et al. Cardiovasc Res. 2006.71: 754-63.	abstract
Genome-wide application of RNAi to the discovery of potential drug targets.	Ito, M, et al. FEBS Lett. 2005.579: 5988-95.	abstract
Stable suppression of gene expression in murine embryonic stem cells by RNAi directed from DNA vector-based short hairpin RNA.	Tang, FC, et al. Stem Cells. 2004.22: 93-9.	abstract
Lentivirus-delivered stable gene silencing by RNAi in primary cells.	Stewart, SA, et al. RNA. 2003.9: 493-501.	abstract
Induction of an interferon response by RNAi vectors in mammalian cells.	Bridge, AJ, et al. Nat Genet. 2003.34: 263-4.	abstract
Promoter choice affects the potency of HIV-1 specific RNA interference.	Boden, D, et al. Nucleic Acids Res. 2003.31: 5033-8.	abstract

Broad Publications

Title	Author / Journal	Abstract
Forward RNAi screens in primary human hematopoietic stem/progenitor cells.	Ali, N et al. Blood 2009.  epublication ahead of print	abstract
Identification of RPS14 as a 5q-syndrome gene by RNA interference screen	Ebert, BL et al.  Nature 2008. 451: 335-9	abstract
Interferon regulatory factors are transciptional regulators of adipogenesis	Eguchi, J et al.  Cell Metab 2008. 7: 86-94	abstract
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity	Firestein, R et al.  Nature 2008. 455: 547-51	abstract
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles	Frohling, SC et al.  Cancer Cell 2007. 12: 501-13	abstract
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3	Jones, DC et al.  Science 2006. 312:1223-7	abstract
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL	Oberdoerffer, S et al.  Science 2008. 321: 686-91	abstract
A mitochondrial protein compendium elucidates complex I disease biology	Pagliarini, DJ et al.  Cell 2008. 134: 112-23	abstract
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis	Scholl CD et al.  JCI 2007. 117:1037-48	abstract
Inhibition of casein kinase 1-epsilon induces cancer-cellselective, PERIOD2-dependent growth arrest	Yang WS, et al.  Genome Biol 2008. 9: R92.	abstract
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.	Boehm, J. S. et al. Cell 2007. 129: 1065-1079.	abstract
Wild-type NRas and KRas perform distinct functions during transformation.	Fotiadou, P. P., Takahashi, C., Rajabi, H. N., Ewen, M. E. Mol. Cell. Biol. 2007. 27: 6742-6755.	abstract
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.	Kim, M. et al. Cell 2006. 125: 1269-1281.	abstract
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.	Moffat, J. et al. Cell 2006. 124: 1283-1298.	abstract
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.	Sancak, Y. et al. Mol. Cell 2007. 25: 903-915.	abstract

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