- Multiple roles of integrin-α3 at the neuromuscular junction.
Multiple roles of integrin-α3 at the neuromuscular junction.
Journal of cell science (2017-04-08)
Jacob A Ross, Richard G Webster, Tanguy Lechertier, Louise E Reynolds, Mark Turmaine, Maximilien Bencze, Yalda Jamshidi, Hakan Cetin, Francesco Muntoni, David Beeson, Kairbaan Hodilvala-Dilke, Francesco J Conti
PMID28386022
要旨
The neuromuscular junction (NMJ) is the synapse between motoneurons and skeletal muscle, and is responsible for eliciting muscle contraction. Neurotransmission at synapses depends on the release of synaptic vesicles at sites called active zones (AZs). Various proteins of the extracellular matrix are crucial for NMJ development; however, little is known about the identity and functions of the receptors that mediate their effects. Using genetically modified mice, we find that integrin-α3 (encoded by