Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP

Journal of inorganic biochemistry (2017-01-29)

Zrinka Rajic, Artak Tovmasyan, Otávio L de Santana, Isabelle N Peixoto, Ivan Spasojevic, Silmar A do Monte, Elizete Ventura, Júlio S Rebouças, Ines Batinic-Haberle

PMID28131001

要旨

We disclose here the studies that preceded and guided the preparation of the metal-based, redox-active therapeutic Mn(III) meso-tetrakis(N-n-butoxyethylpyridyl)porphyrin, MnTnBuOE-2-PyP

材料

製品番号

ブランド

製品内容

186481

Sigma-Aldrich

6-ブロモ-1-ヘキサノール, 97%

T35955

Sigma-Aldrich

p-トルエンスルホニルクロリド, reagent grade, ≥98%