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Merck
  • Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.

Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer.

Immunity (2013-12-03)
Kristi Baker, Timo Rath, Magdalena B Flak, Janelle C Arthur, Zhangguo Chen, Jonathan N Glickman, Inti Zlobec, Eva Karamitopoulou, Matthew D Stachler, Robert D Odze, Wayne I Lencer, Christian Jobin, Richard S Blumberg
要旨

Cancers arising in mucosal tissues account for a disproportionately large fraction of malignancies. Immunoglobulin G (IgG) and the neonatal Fc receptor for IgG (FcRn) have an important function in the mucosal immune system that we have now shown extends to the induction of CD8(+) T cell-mediated antitumor immunity. We demonstrate that FcRn within dendritic cells (DCs) was critical for homeostatic activation of mucosal CD8(+) T cells that drove protection against the development of colorectal cancers and lung metastases. FcRn-mediated tumor protection was driven by DCs activation of endogenous tumor-reactive CD8(+) T cells via the cross-presentation of IgG complexed antigens (IgG IC), as well as the induction of cytotoxicity-promoting cytokine secretion, particularly interleukin-12, both of which were independently triggered by the FcRn-IgG IC interaction in murine and human DCs. FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance.

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Sigma-Aldrich
Anti-FCGRT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution