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Merck

TAp63gamma is required for the late stages of myogenesis.

Cell cycle (Georgetown, Tex.) (2015-03-20)
S Cefalù, A M Lena, B Vojtesek, A Musarò, A Rossi, G Melino, E Candi
要旨

p53 family members, p63 and p73, play a role in controlling early stage of myogenic differentiation. We demonstrated that TAp63gamma, unlike the other p53 family members, is markedly up-regulated during myogenic differentiation in murine C2C7 cell line. We also found that myotubes formation was inhibited upon TAp63gamma knock-down, as also indicated by atrophyic myotubes and reduction of myoblasts fusion index. Analysis of TAp63gamma-dependend transcripts identified several target genes involved in skeletal muscle contractility energy metabolism, myogenesis and skeletal muscle autocrine signaling. These results indicate that TAp63gamma is a late marker of myogenic differentiation and, by controlling different sub-sets of target genes, it possibly contributes to muscle growth, remodeling, functional differentiation and tissue homeostasis.

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製品内容

Sigma-Aldrich
モノクロナール抗β-アクチン マウス宿主抗体, clone AC-15, ascites fluid
Sigma-Aldrich
モノクロナール抗ミオシン (骨格筋, 速筋型) マウス宿主抗体, clone MY-32, ascites fluid