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  • Ferulic acid and benzothiazole dimer derivatives with high binding affinity to beta-amyloid fibrils.

Ferulic acid and benzothiazole dimer derivatives with high binding affinity to beta-amyloid fibrils.

Bioorganic & medicinal chemistry letters (2007-06-05)
Seong Rim Byeon, Yun Jung Jin, Soo Jeong Lim, Ji Hoon Lee, Kyung Ho Yoo, Kye Jung Shin, Seung Jun Oh, Dong Jin Kim
要旨

New ferulic acid and benzothiazole dimer derivatives were synthesized and evaluated by in vitro competition assay using [(125)I]TZDM for their specific binding affinities to Abeta fibrils. In particular, 4a showed the most excellent binding affinity (K(i)=0.53 nM), compared to PIB (K(i)=0.77 nM), for benzothiazole binding sites of Abeta(1-42) fibrils. This result suggests a possibility of a potential AD diagnostic probe for detection of Abeta fibrils.

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製品内容

Sigma-Aldrich
trans-フェルラ酸, 99%
Sigma-Aldrich
trans-フェルラ酸, ≥99%
Supelco
trans-フェルラ酸, ≥99.0% (HPLC)
Supelco
trans-フェルラ酸, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland