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Merck
  • Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose.

Oral absorption of a valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose.

International journal of biological macromolecules (2014-06-01)
In-Hwan Baek, Jung-Soo Kim, Eun-Sol Ha, Gwang-Ho Choo, Wonkyung Cho, Sung-Joo Hwang, Min-Soo Kim
要旨

The aim of this study was to develop a novel valsartan-loaded spray-dried emulsion based on hydroxypropylmethyl cellulose (HPMC) with enhanced oral absorption. The valsartan-loaded redispersible dry emulsion was prepared by using a high-pressure homogenization and spray-drying process with water, Capryol 90, HPMC, and different surfactants, based on the results of the solubility study. The spray-dried emulsions formed small and homogeneous emulsions with a mean droplet emulsion size ranging from 133.5 to 152.5nm at the dispersion state in water. The valsartan-loaded redispersible dry emulsion with HPMC/poloxamer 407 showed enhanced pH-independent valsartan release, resulting in a dramatically enhanced oral bioavailability of valsartan compared to the raw material and commercial product. Therefore, a formulation strategy using the redispersible dry emulsion with HPMC/poloxamer 407 is very effective for the development of a new dosage form containing valsartan.

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Sigma-Aldrich
イルベサルタン, ≥98% (HPLC), powder
Supelco
イルベサルタン, Pharmaceutical Secondary Standard; Certified Reference Material
USP
イルベサルタン, United States Pharmacopeia (USP) Reference Standard
イルベサルタン, European Pharmacopoeia (EP) Reference Standard