- Genotoxicity of tri- and hexavalent chromium compounds in vivo and their modes of action on DNA damage in vitro.
Genotoxicity of tri- and hexavalent chromium compounds in vivo and their modes of action on DNA damage in vitro.
PloS one (2014-08-12)
Zhijia Fang, Min Zhao, Hong Zhen, Lifeng Chen, Ping Shi, Zhiwei Huang
PMID25111056
要旨
Chromium occurs mostly in tri- and hexavalent states in the environment. Hexavalent chromium [Cr(VI)] compounds are extensively used in diverse industries, and trivalent chromium [Cr(III)] salts are used as micronutrients and dietary supplements. In the present work, we report that they both induce genetic mutations in yeast cells. They both also cause DNA damage in both yeast and Jurkat cells and the effect of Cr(III) is greater than that of Cr(VI). We further show that Cr(III) and Cr(VI) cause DNA damage through different mechanisms. Cr(VI) intercalates DNA and Cr(III) interferes base pair stacking. Based on our results, we conclude that Cr(III) can directly cause genotoxicity in vivo.
材料
製品番号
ブランド
製品内容
クロム, foil, light tested, 25x25mm, thickness 0.025mm, permanent polyester support, 99.99+%
クロム, rod, 25mm, diameter 2.0mm, 99.7+%
クロム, rod, 10mm, diameter 2.0mm, 99.7+%
クロム, microfoil, disks, 10mm, thinness 1.0μm, specific density 719μg/cm2, permanent mylar 3.5μm support, 99.99+%
クロム, microfoil, disks, 25mm, thinness 1.0μm, specific density 719μg/cm2, permanent mylar 3.5μm support, 99.99+%
クロム, bar, 100mm x 2mm x 2mm, 99.7+%
クロム, rod, 10mm, diameter 5.0mm, 99.7+%
クロム, microfoil, disks, 10mm, thinness 0.05μm, specific density 37.27μg/cm2, permanent mylar 3.5μm support, 99.99+%
クロム, rod, 100mm, diameter 5.0mm, 99.7+%
クロム, microfoil, disks, 10mm, thinness 0.25μm, specific density 178.7μg/cm2, permanent mylar 3.5μm support, 99.99+%
クロム, microfoil, disks, 25mm, thinness 0.25μm, specific density 178.7μg/cm2, permanent mylar 3.5μm support, 99.99+%
クロム, foil, 50x50mm, thickness 3.0mm, hard, 99.95%
クロム, foil, not light tested, 25x25mm, thickness 0.0125mm, permanent polyester support, 99.99+%
クロム, foil, not light tested, 25x25mm, thickness 0.015mm, permanent polyester support, 99.99+%
クロム, foil, not light tested, 25x25mm, thickness 0.01mm, permanent polyester support, 99.99+%
クロム, foil, not light tested, 25x25mm, thickness 0.03mm, permanent polyester support, 99.99+%
クロム, microfoil, disks, 10mm, thinness 0.025μm, specific density 18.21μg/cm2, permanent mylar 3.5μm support, 99.99+%
クロム, foil, light tested, 25x25mm, thickness 0.05mm, permanent polyester support, 99.99+%
クロム, foil, not light tested, 50x50mm, thickness 0.03mm, permanent polyester support, 99.99+%
クロム, microfoil, disks, 10mm, thinness 0.5μm, specific density 355μg/cm2, permanent mylar 3.5μm support, 99.99+%