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Merck
  • The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B.

The Arabidopsis NIM1 protein shows homology to the mammalian transcription factor inhibitor I kappa B.

The Plant cell (1997-03-01)
J Ryals, K Weymann, K Lawton, L Friedrich, D Ellis, H Y Steiner, J Johnson, T P Delaney, T Jesse, P Vos, S Uknes
要旨

The NIM1 (for noninducible immunity) gene product is involved in the signal transduction cascade leading to both systemic acquired resistance (SAR) and gene-for-gene disease resistance in Arabidopsis. We have isolated and characterized five new alleles of nim1 that show a range of phenotypes from weakly impaired in chemically induced pathogenesis-related protein-1 gene expression and fungal resistance to very strongly blocked. We have isolated the NIM1 gene by using a map-based cloning procedure. Interestingly, the NIM1 protein shows sequence homology to the mammalian signal transduction factor I kappa B subclass alpha. NF-kappa B/I kappa B signaling pathways are implicated in disease resistance responses in a range of organisms from Drosophila to mammals, suggesting that the SAR signaling pathway in plants is representative of an ancient and ubiquitous defense mechanism in higher organisms.