2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

Bioorganic & medicinal chemistry letters (2002-07-13)

Richard L Mackman, Hon C Hui, J Guy Breitenbucher, Bradley A Katz, Christine Luong, Arnold Martelli, Danny McGee, Kesavan Radika, Martin Sendzik, Jeffrey R Spencer, Paul A Sprengeler, James Tario, Erik Verner, Jing Wang

PMID12113832

要旨

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.