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  • Cardiovascular benefits and safety profile of acarbose therapy in prediabetes and established type 2 diabetes.

Cardiovascular benefits and safety profile of acarbose therapy in prediabetes and established type 2 diabetes.

Cardiovascular diabetology (2007-08-19)
Markolf Hanefeld
要旨

Dysglycaemic disease is one of the most important health issues facing the world in the 21st century. Patients with type 2 diabetes and individuals with prediabetes are at risk of developing macrovascular and microvascular complications. Long-term management strategies are therefore required that are effective at controlling dysglycaemia, well tolerated and, ideally, offer additional cardiovascular disease (CVD) risk-reduction benefits. The efficacy, safety and tolerability of the alpha-glucosidase inhibitor acarbose have been well-established in a wide range of patient populations in both clinical and community trials. In addition, acarbose has been shown to reduce cardiovascular complications in type 2 diabetes and prevent hypertension and CVD in individuals with impaired glucose tolerance (IGT). Acarbose has a very good safety profile and, owing to its straightforward, non-systemic mode of action, avoids most adverse events. The most common side-effects of acarbose are mild-to-moderate gastrointestinal complaints that subside as treatment continues. They can be minimised through the use of an appropriate stepwise dosing regimen and careful choice of diet. Acarbose is therefore a valuable option for the management of type 2 diabetes and, as the only oral antidiabetes agent approved for the treatment of prediabetes, can help to improve clinical management across the dysglycaemic disease continuum.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
アカルボース, ≥95% (HPLC)
Supelco
アカルボース, Pharmaceutical Secondary Standard; Certified Reference Material
アカルボース, European Pharmacopoeia (EP) Reference Standard
アカルボース, European Pharmacopoeia (EP) Reference Standard
アカルボース, European Pharmacopoeia (EP) Reference Standard