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  • Very-low-dose combination of perindopril and indapamide as a novel strategy in first-line management of hypertension.

Very-low-dose combination of perindopril and indapamide as a novel strategy in first-line management of hypertension.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension (2001-11-21)
P W de Leeuw
要旨

Most patients with hypertension will need, at some stage, more than one drug to lower their blood pressure. Although monotherapy is still the preferred option for first-line treatment of hypertension, low-dose combination therapy as the initial medication has been increasingly recommended by National and International Guidelines. The use of perindopril/indapamide is an example of such a combination which contains 2 mg of the angiotensin converting enzyme inhibitor perindopril and 0.625 mg of the diuretic indapamide, these doses being respectively half and a quarter of the usual doses in monotherapy. This combination appears to lower blood pressure effectively with a good safety profile. It can be used in the elderly and also in patients with reduced renal function. Studies are underway to assess its efficacy on target organ damage.

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製品内容

USP
インダパミド, United States Pharmacopeia (USP) Reference Standard
インダパミド, European Pharmacopoeia (EP) Reference Standard
Supelco
インダパミド, analytical standard, for drug analysis