- O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Bioorganic & medicinal chemistry letters (2009-08-25)
Baihua Xu, Binhua Lv, Yan Feng, Ge Xu, Jiyan Du, Ajith Welihinda, Zelin Sheng, Brian Seed, Yuanwei Chen
PMID19700318
要旨
Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 6'-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 2'-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1microM.