コンテンツへスキップ
Merck
  • Expression of lymphocyte-derived growth hormone (GH) and GH-releasing hormone receptors in aging rats.

Expression of lymphocyte-derived growth hormone (GH) and GH-releasing hormone receptors in aging rats.

Cellular immunology (2013-06-19)
Douglas A Weigent
要旨

In the present study, we show that higher levels of lymphocyte GH are expressed in spleen cells from aging animals compared to young animals. Further, leukocytes from primary and secondary immune tissues and splenic T and B cells from aging rats all express higher levels of GHRH receptors compared to younger animals. Bone marrow and splenic T cells express the highest levels of GHRH receptor in aging animals. Spleen cells from aging animals showed no significant change in proliferation or GH induction after treatment with GHRH. Taken together, the data for the first time show alterations in GH synthesis and expression of the GHRH receptor on cells of the immune system that may play a role in the immune response in aging.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
モノクロナール抗β-アクチン マウス宿主抗体, clone AC-15, ascites fluid
Sigma-Aldrich
リボ核酸 from torula yeast, Type VI
Sigma-Aldrich
リボ核酸 パン酵母(S. cerevisiae種)由来
Sigma-Aldrich
リボ核酸 from torula yeast, core, Type II-C
Sigma-Aldrich
リボ核酸 from torula yeast, Type IX