- Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
Bioorganic & medicinal chemistry letters (2009-06-12)
Terance Hart, Alba T Macias, Karen Benwell, Teresa Brooks, Jalanie D'Alessandro, Pawel Dokurno, Geraint Francis, Ben Gibbons, Timothy Haymes, Guy Kennett, Sean Lightowler, Howard Mansell, Natalia Matassova, Anil Misra, Anthony Padfield, Rachel Parsons, Robert Pratt, Alan Robertson, Steven Walls, Melanie Wong, Stephen Roughley
PMID19515560
要旨
We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.
材料