Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643.

Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643.

The Journal of antibiotics (1999-12-02)

M S Brown, J P Dirlam, H A McArthur, E L McCormick, B K Morse, P A Murphy, T N O'Connell, M Pacey, D M Rescek, J Ruddock, R G Wax

PMID10580387

要旨

Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.