- Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
Bioorganic & medicinal chemistry (2011-11-15)
Claudia Bello, Giovanna Dal Bello, Michele Cea, Aimable Nahimana, Dominique Aubry, Anna Garuti, Giulia Motta, Eva Moran, Floriana Fruscione, Paolo Pronzato, Francesco Grossi, Franco Patrone, Alberto Ballestrero, Marc Dupuis, Bernard Sordat, Kaspar Zimmermann, Jacqueline Loretan, Markus Wartmann, Michel A Duchosal, Alessio Nencioni, Pierre Vogel
PMID22079865
要旨
New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-D-ribitol (13, IC(50) ∼2 μM) and its C(18)-analogues (IC(50) <10 μM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) ∼8 μM) growth of JURKAT cells.