- N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.
N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.
Acta neurologica Scandinavica (1988-08-01)
G Nappi, F Facchinetti, E Martignoni, F Petraglia, E Sinforiani, G Bono, A R Genazzani
PMID2845700
要旨
Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.
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