- [Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].
[Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].
Biomeditsinskaia khimiia (2013-05-09)
V O Tkachev, M V Zaĭkovskaia, A V Troitskiĭ, N G Luzgina, V A Shkurupiĭ
PMID23650725
要旨
The effects of oxidized dextrans of different molecular weight on reactive oxygen species production and transmembrane mitochondrial potential of macrophages and neutrophils have been studied in vivo and in vitro. Oxidised dextrans demonstrated moderate direct antioxidant ability but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.
材料
製品番号
ブランド
製品内容