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Merck
  • Total syntheses of (-)-hanishin, (-)-longamide B, and (-)-longamide B methyl ester via a novel preparation of N-substituted pyrrole-2-carboxylates [corrected].

Total syntheses of (-)-hanishin, (-)-longamide B, and (-)-longamide B methyl ester via a novel preparation of N-substituted pyrrole-2-carboxylates [corrected].

Organic letters (2012-02-10)
Guolin Cheng, Xinyan Wang, Hailin Bao, Chuanjie Cheng, Nan Liu, Yuefei Hu
要旨

A novel preparation of N-substituted pyrrole-2-carboxylates has been developed based upon 1,3-dipolar cycloaddition and a conventional hydrogenolysis. By using this method as the key step, total syntheses of natural alkaloids (-)-hanishin, (-)-longamide [corrected] B, and (-)-longamide [corrected] B methyl ester were accomplished in the highest overall yields, respectively.

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製品番号
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製品内容

Sigma-Aldrich
ピロール-2-カルボン酸, 99%