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Merck
  • Sequential C-N and C-O bond formation in a single pot: synthesis of 2H-benzo[b][1,4]oxazines from 2,5-dihydroxybenzaldehyde and amino acid precursors.

Sequential C-N and C-O bond formation in a single pot: synthesis of 2H-benzo[b][1,4]oxazines from 2,5-dihydroxybenzaldehyde and amino acid precursors.

Organic letters (2012-01-06)
Javed Iqbal, Neelima D Tangellamudi, Balakrishna Dulla, Sridhar Balasubramanian
要旨

Functionalized β-aryl alanine ester derivatives were found to undergo rapid C-N and C-O bond formation with quinol carbonyl compounds to afford 2H-benzo[b][1,4]oxazines in good to excellent yields. This unprecedented finding reported herein offers a straightforward, highly efficient, and rapid method for the synthesis of 2H-benzo[b][1,4]oxazines.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
2,5-ジヒドロキシベンズアルデヒド, 98%