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Merck

Mild addition of nucleophiles to pyridine-N-oxides.

Organic letters (2011-03-08)
Allyn T Londregan, Sandra Jennings, Liuqing Wei
要旨

A general and facile one-pot procedure for the synthesis of 2-substituted pyridines from the corresponding pyridine-N-oxides and nucleophiles is presented as a mild alternative to S(N)Ar chemistry. A variety of nucleophiles and heterocyclic-N-oxides participate effectively in this transformation, which uses the phosphonium salt, PyBroP, as a means of substrate activation.

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製品内容

Sigma-Aldrich
ピリジンN-オキシド, 95%