コンテンツへスキップ
Merck
  • Effects of oral epigallocatechin gallate on the oral pharmacokinetics of verapamil in rats.

Effects of oral epigallocatechin gallate on the oral pharmacokinetics of verapamil in rats.

Biopharmaceutics & drug disposition (2009-02-20)
Joong-Hwa Chung, Dong-Hyun Choi, Jun-Shik Choi
要旨

Verapamil is known to be a P-glycoprotein (P-gp) substrate and norverapamil is formed via hepatic cytochrome P450 (CYP 3A) in the rat. Epigallocatechin gallate (EGCG), a flavonoid, was reported to be an inhibitor of both P-gp and CYP3A. Hence, it could be expected that EGCG could alter the pharmacokinetics of verapamil. In this study, 9 mg/kg verapamil was administered orally to Sprague-Dawley rats 30 min after the oral administration of 2 and 10 mg/kg of oral EGCG. Compared with the controls, the AUC values of both verapamil (74.3% and 111% increase for 2 and 10 mg/kg EGCG, respectively) and norverapamil (51.5% and 87.2% increase for 2 and 10 mg/kg EGCG, respectively) were significantly greater in the presence of EGCG. However, compared with the controls, both the AUC and the relative bioavailability of verapamil were significantly (p<0.01) increased by 74.3-111% in the presence of EGCG. The likely explanation is inhibition of P-gp. Inhibition of CYP3A would increase the AUC of verapamil but decrease the AUC of norverampil. However, inhibition of P-gp would lead to an increase of AUC of both verapamil and norverapamil.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
(±)-ノルベラパミル 塩酸塩, ≥98% (HPLC)