- Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives.
Synthesis and evaluation of in vitro antiviral activity of novel phenoxy acetic acid derivatives.
Journal of enzyme inhibition and medicinal chemistry (2008-10-28)
M Shahar Yar, M Afroz Bakht, A A Siddiqui, M M Abdullah, Erik De Clercq
PMID18951282
要旨
Several substituted phenoxy acetic acid derived pyrazolines were synthesized by the reaction between 2-{4-[3-(2,4-dihydroxyphenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy} acetic acid and substituted acid hydrazides and were tested for their in vitro cytotoxicity and antiviral activity. None of the compounds showed any specific antiviral activity [50% antivirally effective concentration (EC(50)) > or = 5-fold lower than minimum cytotoxic concentration]. The most cytotoxic of the series was 2-{4-[3-(2,4-dihydroxyphenyl)-1-(2-hydroxybenzoyl-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid (3(j)), with a minimum cytotoxic concentration of 0.16 microg/mL in human embryonic lung (HEL) cells.