- A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
A modular flow reactor for performing Curtius rearrangements as a continuous flow process.
Organic & biomolecular chemistry (2008-04-19)
Marcus Baumann, Ian R Baxendale, Steven V Ley, Nikzad Nikbin, Christopher D Smith, Jason P Tierney
PMID18421389
要旨
The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.