コンテンツへスキップ
Merck
  • [Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].

[Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].

Yao xue xue bao = Acta pharmaceutica Sinica (2003-08-02)
Fa-qing Ye, Li Chen, Jin-min Huang
要旨

To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol. Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested. Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis. Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
2-メチル-4(5)-ニトロイミダゾール, 99%
Supelco
2-メチル-4(5)-ニトロイミダゾール, Pharmaceutical Secondary Standard; Certified Reference Material
2-メチル-4(5)-ニトロイミダゾール, European Pharmacopoeia (EP) Reference Standard
Supelco
Menidazole, VETRANAL®, analytical standard