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Merck

Block of spatial learning by mGluR agonist tADA in rats.

Neuropharmacology (1995-05-01)
G Riedel, W Wetzel, A P Kozikowski, K G Reymann
要旨

As demonstrated recently, mGluRs are involved in some forms of learning. We thus investigated the effect of tADA (trans-azetidine-2,4-dicarboxylic acid) applied intracerebroventricularly prior to learning a spatial alternation paradigm. Compared to controls, tADA treated animals were amnesic when tested for retention 24 hr after training. Effects of state-dependency were excluded. These data and our earlier work indicate that both mGluR agonists and antagonists can have memory-disrupting effects.