- Block of spatial learning by mGluR agonist tADA in rats.
Block of spatial learning by mGluR agonist tADA in rats.
Neuropharmacology (1995-05-01)
G Riedel, W Wetzel, A P Kozikowski, K G Reymann
PMID7566491
要旨
As demonstrated recently, mGluRs are involved in some forms of learning. We thus investigated the effect of tADA (trans-azetidine-2,4-dicarboxylic acid) applied intracerebroventricularly prior to learning a spatial alternation paradigm. Compared to controls, tADA treated animals were amnesic when tested for retention 24 hr after training. Effects of state-dependency were excluded. These data and our earlier work indicate that both mGluR agonists and antagonists can have memory-disrupting effects.