- Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
Bioorganic & medicinal chemistry letters (2012-12-26)
Murat Bozdag, Tobias Dreker, Christophe Henry, Paolo Tosco, Maura Vallaro, Roberta Fruttero, Andrea Scozzafava, Fabrizio Carta, Claudiu T Supuran
PMID23265898
要旨
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine moieties.
材料
製品番号
ブランド
製品内容
Sigma-Aldrich
ペプチジルアルギニンデイミナーゼ ウサギ骨格筋由来, buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)