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Merck
  • Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection.

Synthesis and evaluation of a tri-tyrosine decorated dextran MR contrast agent for vulnerable plaque detection.

Chemical communications (Cambridge, England) (2011-04-02)
Anne Beilvert, Roger Vassy, Emmanuelle Canet-Soulas, Olivier Rousseaux, Luc Picton, Didier Letourneur, Frédéric Chaubet
要旨

This communication reports the synthesis, characterization and in vivo evaluation in mice of a new tri-tyrosine conjugated MR contrast agent, which may help to identify vulnerable plaques in atherosclerosis by targeting the lipid core.