- M-cadherin and its sisters in development of striated muscle.
M-cadherin and its sisters in development of striated muscle.
Cell and tissue research (1999-04-13)
U Kaufmann, B Martin, D Link, K Witt, R Zeitler, S Reinhard, A Starzinski-Powitz
PMID10199979
要旨
Cadherins are calcium-dependent, transmembrane intercellular adhesion proteins with morphoregulatory functions in the development and maintenance of tissues. In the development of striated muscle, the expression and function of mainly M-, N-, and R-cadherin has been studied so far. While these three cadherins are expressed in skeletal muscle cells, of these only N-cadherin is expressed in cardiac muscle. In this review, M-, N-, and R-cadherin are discussed as important players in the terminal differentiation and possibly also in the commitment of skeletal muscle cells. Furthermore, reports are described which evaluate the essential role of N-cadherin in the formation of heart tissue.