SRP5319

PI3K (p110-α/p55-γ), active, His tagged human

PRECISIO^®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 別名: p110-alpha, p55-gamma
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• リコンビナント: expressed in baculovirus infected Sf9 cells
• 製品種目: PRECISIO^®
• アッセイ: ≥70% (SDS-PAGE)
• 形状: buffered aqueous glycerol solution
• 比活性: 11.2-16.8 nmol/min·mg
• 分子量: ~111 kDa (p110α); ~61 kDa (p85γ)
• NCBIアクセッション番号: NM_006218
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... PIK3CA(5290)

詳細

詳細

PI3K (p110alpha/p55gamma) or Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position which serve as second messengers in growth signaling pathways. PI3K comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in the PI3K has been associated with insulin resistance and plays an important role in glucose homeostasis in vivo. PI3K also plays an essential role in the development and induction of mast cells in normal and pathogenic immune responses.

物理的形状

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

調製ノート

開封後は少量ずつに分注して－70℃で保管してください。操作を反復したり凍結融解を何度も繰り返したりしないでください。

法的情報

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H315,H319,H360D
• 注意書き: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable