SML3028

Apostatin-1

≥98% (HPLC)

• 別名: N-Cycloheptyl-?-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]-benzeneacetamide
• 実験式（ヒル表記法）: C₁₉H₂₇N₃OS
• CAS番号: 2559703-06-7
• 分子量: 345.50
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(C(C1=CC=CC=C1)SC2=NCCN2C)NC3CCCCCC3
• InChI Key: OXBMBNASDMMXSA-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Apostatin-1 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. Apostatin-1 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently Apostatin-1 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.

cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable