SML2525

Tafluprost

≥98% (HPLC)

• 別名: (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl ester, AFP-168
• 実験式（ヒル表記法）: C₂₅H₃₄F₂O₅
• CAS番号: 209860-87-7
• 分子量: 452.53
• MDL番号: MFCD08062150
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: oil
• 光学活性: [α]/D +20 to +25°, c = 1 in chloroform-d
• 色: colorless to yellow
• 保管温度: −20°C
• InChI: 1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3+,15-14+
• InChI Key: WSNODXPBBALQOF-ZHDUIJGQSA-N

詳細

生物化学的／生理学的作用

Taflupost is a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. It has high affinity and selectivity for the fluoroprostaglandin (FP) receptor PGF2α. Tafluprost is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Tafluprost is a pro-drug. The active metabolite is the free acid.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H361d
• 注意書き: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Repr. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable