SML1749

Narasin Ready Made Solution

1 mg/ml in DMSO

• 別名: (2R)-2-[(2R,3S,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3,5-dimethyloxan-2-yl]butanoic acid, (4S)-4-Methylsalinomycin, A 28086A, Antibiotic A 28086A, Antibiotic C 7819B, C 7819B, Monteban, Narasin A, Narasul
• 実験式（ヒル表記法）: C₄₃H₇₂O₁₁
• CAS番号: 55134-13-9
• 分子量: 765.03
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: Streptomyces aureofaciens
• 品質水準: 200
• 形状: solution
• 濃度: 1 mg/ml in DMSO
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1
• InChI Key: VHKXXVVRRDYCIK-CWCPJSEDSA-N

詳細

生物化学的／生理学的作用

Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. Narasin inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.

In addition, Narasin inhibits Dengue virus (DENV) at the post-entry stage of viral replication during DENV infection. The inhibition of DENV involves a non-cytotoxic mechanism, therefore, Narasin can be possibly considered as therapeutic agent against DENV infection. A dose dependent curve (0.01-5 μM) showed that Narasin has 50% inhibitory concentration at less than 1 μM against all four serotypes of DENV. The IC₅₀ (μM) of Narasin against four different DENV serotypes was 0.05-0.65 μM.

その他情報

Narasin solution is provided at 1.307 mM (1 mg/ml). Typical final concentration for use in cell culture is 0.01-5 μM. Stable at ­­­–20 °C for at least 2 years.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup
• 引火点(℃): 87 °C - closed cup