SML0378

Ralfinamide mesylate

≥98% (HPLC)

• 別名: (2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate
• 実験式（ヒル表記法）: C₁₇H₁₉FN₂O₂ · CH₃SO₃H
• CAS番号: 202825-45-4
• 分子量: 398.45
• MDL番号: MFCD19690932
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825378
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 光学活性: [α]/D 10 to 15° (c=1 HOAc)
• 色: white to beige
• 溶解性: H₂O: >15 mg/mL
• 保管温度: 2-8°C
• SMILES記法: CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O
• InChI: 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-6-8-15(9-7-13)22-11-14-4-2-3-5-16(14)18;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
• InChI Key: CHQVNINIGBRKGZ-YDALLXLXSA-N

詳細

生物化学的／生理学的作用

Ralfinamide is a mixed sodium and N-type calcium channel blocker. Inhibiton is voltage-dependent, with higher potency against inactivated channels. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents.

特徴および利点

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable