SMB00579

Tacalcitol

≥99% (HPLC)

• 別名: (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol, 1α,24R-dihydroxycholecalciferol, 1α,24R-dihydroxyvitamin D₃
• 実験式（ヒル表記法）: C₂₇H₄₄O₃
• CAS番号: 57333-96-7
• 分子量: 416.64
• MDL番号: MFCD00866623
• UNSPSCコード: 12352205
• PubChem Substance ID: 329825068
• NACRES: NA.79

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥99% (HPLC)
• フォーム: powder
• テクニック: HPLC: suitable
• 色: white to off-white
• 保管温度: −20°C
• SMILES記法: C[C@]1(CCC/2)[C@](CC[C@]1([H])[C@H](C)CC[C@@H](O)C(C)C)([H])C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C
• InChI: 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
• InChI Key: BJYLYJCXYAMOFT-RSFVBTMBSA-N

詳細

詳細

Tacalcitol is a synthetic vitamin D₃ analog.[1] It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3.[2]

生物化学的／生理学的作用

Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin.[3] Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis.[1] Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease.[2]

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300
• 注意書き: P301 + P330 + P331 + P310
• 危険有害性の分類: Acute Tox. 1 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable