SAB5702444

Anti-Rad50 Antibody, clone 5M2K10, Rabbit Monoclonal

• 別名: NBSLD, RAD502, hRad50
• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: rabbit
• 品質水準: 100
• 物質: colorless
• クローン: 5M2K10, monoclonal
• 形状: liquid
• 分子量: 154 kDa
• 化学種の反応性: rat, human, rat
• 濃度: 0.85 mg/mL
• テクニック: immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000
• 色: colorless
• アイソタイプ: IgG
• 免疫原配列: RCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIV
• UniProtアクセッション番号: Q92878
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... RAD50(10111)

詳細

詳細

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Rad50 (Q92878).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

アプリケーション

WB,IP

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1