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Merck

SAB4502158

Sigma-Aldrich

Anti-BRP44L antibody produced in rabbit

affinity isolated antibody

別名:

MPC1, Mitochondrial pyruvate carrier 1, Brain protein 44-like protein

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

形状

buffered aqueous solution

分子量

antigen 12 kDa

化学種の反応性

rat, mouse, human

濃度

~1 mg/mL

テクニック

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBIアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... BR44L(51660)

詳細

MPC1 (mitochondrial pyruvate carrier 1) gene is mapped to human chromosome 6q27. MPC1 encodes a 12kDa, protein containing five exons and two membrane spanning α helixes. Anti-BRP44L Antibody detects endogenous levels of total BRP44L protein.

免疫原

The antiserum was produced against synthesized peptide derived from human BRP44L.

Immunogen Range: 11-60

アプリケーション

Anti-BRP44L antibody produced in rabbit has been used to check the effect of mitochondrial TOM70 (translocase of the outer membrane protein 70) on MPC1 (mitochondrial pyruvate carrier 1) expression.

生物化学的/生理学的作用

MPC1 (mitochondrial pyruvate carrier 1) is a key player in pyruvate metabolism. It transports pyruvate into the inner mitochondrial matrix. Lowered MPC1 expression, elevates glycolysis due to a shift in metabolism to fatty acid oxidation. This accounts for the pathogenesis of cancer and other diseases. Downregulation of this gene is observed in colon adenocarcinoma.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)
Sandoval IT, et al.
eLife, 6(28), e22706-e22706 (2017)
TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer
Filadi R, et al.
Current Biology, 28(3), 369-382 (2018)
Defective expression of the mitochondrial-trna modifying enzyme GTPBP3 triggers AMPK-mediated adaptive responses involving complex I assembly factors, uncoupling protein 2, and the mitochondrial pyruvate carrier
Martinez-Zamora A, et al.
PLoS ONE, 10(12), e0144273-e0144273 (2015)
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells
Li X, et al.
Testing, 8(28), 46363-46363 (2017)
Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses
Li X, et al.
Oncotarget, 7(48), 79981-79994 (2016)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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