SAB4300452

Anti-PRKAA1/PRKAA2 (Ab-174/172) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-AMPK antibody produced in rabbit, Anti-AMPK2 antibody produced in rabbit, Anti-AMPKa1 antibody produced in rabbit, Anti-protein kinase, AMP-activated, alpha 1 catalytic subunit antibody produced in rabbit
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~63 kDa
• 化学種の反応性: mouse, human, rat
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (L-R-T-S-C)
• NCBIアクセッション番号: NP_006242.5; NP_006243.2
• UniProtアクセッション番号: P54646
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PRKAA1(5562) , PRKAA2(5563)

詳細

免疫原

Peptide sequence around aa. 172-176/170-174 (L-R-T-S-C), according to the proteins PRKAA1/PRKAA2.

特徴および利点

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ターゲットの説明

Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable