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Merck
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資料

Q109

Sigma-Aldrich

6-Nitroquipazine maleate salt

solid

別名:

6-Nitro-2-(1-piperazinyl)quinoline maleate salt, Du 24565

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About This Item

実験式（ヒル表記法）:
C13H14N4O2 · C4H4O4
CAS番号:
77372-73-7
分子量:
374.35
MDL番号:
MFCD00153868
UNSPSCコード:
12352202
PubChem Substance ID:
24278116
NACRES:
NA.77

形状

solid

色

yellow

溶解性

0.1 M HCl: 16 mg/mL
H2O: 5 mg/mL
methanol: 6 mg/mL
0.1 M NaOH: insoluble

保管温度

2-8°C

SMILES記法

[H]\C(=C(/[H])C(O)=O)C(O)=O.[O-][N+](=O)c1ccc2nc(ccc2c1)N3CCNCC3

InChI

1S/C13H14N4O2.C4H4O4/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16;5-3(6)1-2-4(7)8/h1-4,9,14H,5-8H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI Key

LXOHMGALVZOYRF-BTJKTKAUSA-N

遺伝子情報

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

生物化学的／生理学的作用

Potent and selective serotonin transport blocker.

特徴および利点

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

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C A Mathis et al.
The Journal of pharmacy and pharmacology, 46(9), 751-754 (1994-09-01)
The in-vitro inhibition constants (Ki) of nine structural analogues of the potent 5-hydroxytryptamine (5-HT)-uptake inhibitor, 6-nitroquipazine, were determined to assess the structure-affinity relationship of these derivatives. The goal of these studies was to determine those positions on 6-nitroquipazine that could
K Classen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 326(3), 198-202 (1984-06-01)
Rat brain cortex slices were prepared in order to study the influence of DU 24565 (6-nitroquipazine) and quipazine on the accumulation of tritium, and to investigate the effects of DU 24565 on the electrically evoked (3 Hz) tritium overflow from
M Okada et al.
The European journal of neuroscience, 11(1), 1-9 (1999-02-13)
To clarify the effects of adenosine receptor subtypes (A1, A2 and A3) on hippocampal serotonin (5-HT) release and 5-HT reuptake activity, hippocampal extracellular 5-HT levels were determined in vivo by microdialysis in freely moving rats. Selective 5-HT reuptake inhibitor (SSRI)
K Hashimoto et al.
European journal of pharmacology, 180(2-3), 273-281 (1990-05-16)
6-Nitroquipazine is a very potent and selective inhibitor of neuronal 5-hydroxytryptamine (5-HT; serotonin) uptake. We have characterized the specific binding of [3H]6-nitroquipazine to rat brain membranes at 22 degrees C. The present results indicate the presence of a single saturable
Byoung Se Lee et al.
Bioorganic & medicinal chemistry, 11(23), 4949-4958 (2003-11-08)
3-(3-[18F]Fluoropropyl)-6-nitroquipazine ([18F]FPNQ) as a 5-HT transporter imaging agents was designed, synthesized, and evaluated. FPNQ was selected due to its potent in vitro biological activity (K(i)=0.32 nM) in rat brain cortical membranes. The 18F-labeled FPNQ was prepared by reaction of the
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